Contact Information

CURE/UCLA
VA Greater Los Angeles Healthcare System
11301 Wilshire Boulevard
Building 114, Room 217
Los Angeles, CA 90073
Tel: (310) 478-3711 x43343
Fax:(310) 268-4811
E-mail: yakiba@verizon.net

Biosketch

Regulation of mucosal defenses such as intracellular pH, bicarbonate- mucus secretion and blood flow in response to luminal content such as acid, CO2, nutrients, etc in the gastrointestinal tract under physiological and pathological conditions.

Selected References

Akiba Y, Jung M, Ouk S, Kaunitz JD. A novel small molecule CFTR inhibitor attenuates HCO3- secretion and duodenal ulcer formation in rats. Am J Physiol 289: G753-G759, 2005.

Akiba Y, Nakamura M, Nagata H, Kaunitz JD, Ishii H. Acid-sensing pathways in rat gastrointestinal tract. J Gastroenterol 37 suppl 14: 133-138, 2002.

Akiba Y, Furukawa O, Guth PH, Engel E, Nastaskin I, Sassani P, Pushkin A, Kurtz I, Kaunitz JD. Cellular bicarbonate protects rat duodenal mucosa from acid-induced injury. J Clin Invest 108: 1807-1816, 2001.

Akiba Y, Guth PH, Engel E, Nastaskin I, Kaunitz JD. Dynamic regulation of mucus gel thickness in rat duodenum. Am J Physiol 279: G437-G447, 2000.

Akiba Y, Kaunitz JD. Regulation of intracellular pH and mucosal blood flow in rat duodenal epithelium in vivo. Am J Physiol 276: G293-G302, 1999.