Contact Information

Center for Neurovisceral Sciences & Women's Health
11301 Wilshire Boulevard
Building 115, Room 223
Los Angeles, CA 90073
On-campus mail: BVA Bldg. 115 Room 223 179247
Tel: (310) 312-9276
Fax: (310) 794-2864
E-mail: linchang@ucla.edu
Web: www.uclacns.org, www.cure.med.ucla.edu

Biosketch

Lin Chang is a Professor of Medicine in the Division of Digestive Diseases and Department of Medicine at the David Geffen School of Medicine at UCLA. She is the Co-Director and Head of the Clinical Program at the Center for Neurovisceral Sciences & Women's Health and Director of the Women's Digestive Health Center at UCLA. Dr. Chang's main area of research is the pathophysiology of irritable bowel syndrome (IBS) with particular interests in the overlap of IBS with fibromyalgia, as well as gender differences and neuroendocrine alterations. She is principal investigator on two NIH grants studying the central and peripheral mechanisms underlying IBS. She has also been an investigator on a number of clinical trials for functional bowel disorders. She is a member of the American College of Gastroenterology, the American Gastroenterological Association, and the Society for Neuroscience. Dr. Chang is the Co-chair of the Rome III subcommittee on Gender, Age and Cultural Influences on Functional Bowel Disorders. She is currently serving on the FDA GI Advisory Committee. Dr. Chang has multiple publications in peer-reviewed journals and textbooks. She has given over 100 lectures at national and local meetings.

Selected References

Chang L, Mayer EA, FitzGerald L, Stains J, Naliboff B. Differences in somatic perception in patients with irritable bowel syndrome with and without fibromyalgia. Pain 84:297-307, 2000.

Chang L, Munakata J, Mayer EA, Schmulson MJ, Johnson TD, Bernstein CN, Saba L, Naliboff B, Anton PA, Matin K. Perceptual responses in patients with inflammatory and functional bowel disease. Gut 47:497-505, 2000.

Chang, L, Berman S, Mayer EA, Suyenobu B, Derbyshire SWG, Naliboff BD Vogt B, FitzGerald LZ, Mandelkern MA. Brain responses to acute visceral and somatic stimuli in patients with irritable bowel syndrome and fibromyalgia. Am J Gastroenterol 98:1354-1361, 2003.

Chang L, Ameen VZ, Dukes G, McSorley DJ, Mayer EA. A dose-ranging, phase II study of the efficacy and safety of alosetron hydrochloride (Lotronex®) in men with diarrhea-predominant IBS. Am J Gastroenterol 100:115-123, 2005.

Tillisch K, Labus J, Naliboff BD, Bolus R, Shetzline M, Mayer EA, Chang L. Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome. Am J Gastroenterol 100(4):896-904, 2005.

Dunckley P, Wise R, Painter D, Brooks J, Tracey I, Aziz Q, Chang L. Cortical processing of visceral and somatic stimulation - differentiating pain intensity from unpleasantness. Neurosci (2005).

Mayer EA, Berman S, Suyenobu B, Labus J, Mandelkern MA, Naliboff B, Chang L. Brain responses to visceral pain between male patients with irritable bowel syndrome and ulcerative colitis. Pain (2005).